FlowPoint Bio

The hardest cell therapies to engineer are the ones that matter most.

Size Matters.

NEST safely delivers large genetic payloads directly into the nucleus — without viral vectors or electroporation.
Transfect any cell type with confidence.

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NEST was built for the programs that existing tools have failed.

Academic Research Labs

Working with HSCs, iPSCs, or other fragile, non-dividing cell types? Engineering multigene or large constructs that push past what viral vectors can carry?

Electroporation kills cell viability. Vectors struggle to deliver your payloads reliably. NEST delivers constructs of any type, with sizes exceeding 10kB directly into the nucleus. The best part? We deliver whatever you want with >90% viability and can handle cell types for which current tools are mechanistically inadequate.

→ Built for stem cell programs, large transgene delivery, and complex circuit engineering.

Early-Stage Biotech Developers

Building a next-generation ex-vivo program and choosing your delivery process? Don't let your tools constrain you.

NK cell, iPSC-derived, and complex CAR-T programs are constrained not by biology, but by what your delivery tool can handle. NEST removes the ceiling on payload size, cell type, and throughput. We can scale with you from lab bench to bioreactor.

→ Designed for cell therapy development teams building programs that demand more.

The Platform

How NEST Works

Two physical advantages drive every payload delivery: cells flow continuously through NEST's channels, and nanolancets pierce both membranes on the way through. No electricity, no viral packaging, no optimization per cell type.

01

Cells Flow Through

Your cell suspension flows continuously through arrays of microfluidic channels sized to match your cell type — no batch setup, no high-voltage pulse, no waiting.

Continuous flow Cell-type adaptable <30 min to expression
02

Membranes are gently pierced

Silicon nanolancets physically pierce the plasma and nuclear membranes as each cell passes. Payload of nearly any size and shape is delivered directly into the nucleus. No diffusion barrier.

Direct nuclear access >10kB payloads >90% viability

Modality-agnostic. NEST is a physical delivery tool — not a reagent, vector, or editing modality. It works with CRISPR RNP, plasmid DNA, mRNA, or any combination. Payload chemistry is your choice. Deliver it with confidence.

Our Partners

Backed By The Best

Our science is rigorously validated and the technology is supported by some of the world's leading institutions.

Let's work together

Ready to Connect?

Whether you're running a stem cell program, building a next-generation ex-vivo therapy, or just want to see the data, we want to hear from you. Tell us about your program and we'll be in touch.